| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10588717 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
A facile one-pot zirconium tetrachloride and sodium iodide mediated iodination protocol has been applied for the synthesis of benzothiazolo-4β-anilino-podophyllotoxin (5a-h) and benzothiazolo-4β-anilino-4-O-demethylepipodophyllotoxin (6a-h) congeners. Some of these compounds have shown significant in vitro cytotoxicity on selected human cancer cell lines apart from DNA topoisomerase-II inhibition activity.
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Authors
Ahmed Kamal, B. Ashwini Kumar, Paidakula Suresh, Nagula Shankaraiah, M. Shiva Kumar,