| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10588733 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
The synthesis, structure-activity relationships (SAR) and biological evaluation of thiazole based tricyclic inhibitors of IKK2 are described. Compound 9 was determined to be efficacious in a murine model for rheumatoid arthritis.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: Synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis](/preview/png/10588733.png "First Page Preview: Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: Synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis")
Authors
Alaric J. Dyckman, Charles M. Langevine, Claude Quesnelle, James Kempson, Junqing Guo, Patrice Gill, Steven H. Spergel, Scott H. Watterson, Tianle Li, David S. Nirschl, Kathleen M. Gillooly, Mark A. Pattoli, Kim W. McIntyre, Laishun Chen,