| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10588743 | Bioorganic & Medicinal Chemistry Letters | 2011 | 6 Pages |
Abstract
The development and synthesis of potent p38α MAP kinase inhibitors containing a pyridazinone platform is described. Evolution of the p38α selective pyridopyridazin-6-one series from the p38α/β dual inhibitor 2H-quinolizin-2-one series will be discussed in full detail.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Robert M. Tynebor, Meng-Hsin Chen, Swaminathan R. Natarajan, Edward A. O'Neill, James E. Thompson, Catherine E. Fitzgerald, Stephen J. O'Keefe, James B. Doherty,