CoMFA and CoMSIA studies on 5-hydroxyindole-3-carboxylate derivatives as 5-lipoxygenase inhibitors: Generation of homology model and docking studies

In this Letter, CoMFA and CoMSIA were performed on a series of 2-substituted 5-hydroxyindole-3-carboxylate derivatives as potent 5-LOX inhibitors. The data generated from the present study will further help design and validate novel and potent 5-LOX inhibitors.