Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10588761 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
The synthesis and biological evaluation of potent and selective anaplastic lymphoma kinase (ALK) inhibitors from a novel class of 2,4-diaminopyrimidines, incorporating 2,3,4,5-tetrahydro-benzo[d]azepine fragments, is described. An orally bioavailable analogue (18) that displayed antitumor efficacy in ALCL xenograft models in mice was identified and extensively profiled.
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Authors
Eugen F. Mesaros, Jason P. Burke, Jonathan D. Parrish, Benjamin J. Dugan, Andrew V. Anzalone, Thelma S. Angeles, Mark S. Albom, Lisa D. Aimone, Matthew R. Quail, Weihua Wan, Lihui Lu, Zeqi Huang, Mark A. Ator, Bruce A. Ruggeri, Mangeng Cheng,