| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10588763 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
The synthesis and SAR development of a pyrazolo[1,5-a]pyrimidine-based structural series is described which led to the identification of potent, selective CHK1 inhibitors such as 17r.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach-Part 1](/preview/png/10588763.png "First Page Preview: Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach-Part 1")
Authors
Michael P. Dwyer, Kamil Paruch, Marc Labroli, Carmen Alvarez, Kerry M. Keertikar, Cory Poker, Randall Rossman, Thierry O. Fischmann, Jose S. Duca, Vincent Madison, David Parry, Nicole Davis, Wolfgang Seghezzi, Derek Wiswell, Timothy J. Guzi,