Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10588778 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
In continuation of our study on medicinal plants of Cameroon, stem barks of Polyalthia suaveolens were phytochemically studied. This investigation yielded a new indolosesquiterpene alkaloid, named polysin (1) and four hitherto known alkaloids (2-5). Polysin (1) appeared as a competitive reversible inhibitor (Ki = 10 μM) of phosphofructo kinase (PFK) of Trypanosoma brucei with respect to fructose-6-phosphate (Ki/KM = 0.05) and could be used in the design of new trypanocidal drugs. The other isolated compounds (2-5) also exhibited interesting inhibitory effects on selected glycolytic enzymes (PFK, glyceraldehyde-3-phosphate dehydrogenase and aldolase).
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Authors
Igor Ngantchou, Barthélemy Nyasse, Colette Denier, Casimir Blonski, Véronique Hannaert, Bernd Schneider,