Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10588799 | Bioorganic & Medicinal Chemistry Letters | 2010 | 7 Pages |
Abstract
We have designed and synthesized a novel series of α-amino cyclic boronates and incorporated them successfully in several acyclic templates at the P1 position. These compounds are inhibitors of the HCV NS3 serine protease, and structural studies show that they inhibit the NS3 protease by trapping the Ser-139 hydroxyl group in the active site. Synthetic methodologies and SARs of this series of compounds are described.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xianfeng Li, Yong-Kang Zhang, Yang Liu, Charles Z. Ding, Qun Li, Yasheen Zhou, Jacob J. Plattner, Stephen J. Baker, Xuelei Qian, Dazhong Fan, Liang Liao, Zhi-Jie Ni, Gemma V. White, Jackie E. Mordaunt, Linos X. Lazarides, Martin J. Slater,