Article ID Journal Published Year Pages File Type
10588799 Bioorganic & Medicinal Chemistry Letters 2010 7 Pages PDF
Abstract
We have designed and synthesized a novel series of α-amino cyclic boronates and incorporated them successfully in several acyclic templates at the P1 position. These compounds are inhibitors of the HCV NS3 serine protease, and structural studies show that they inhibit the NS3 protease by trapping the Ser-139 hydroxyl group in the active site. Synthetic methodologies and SARs of this series of compounds are described.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
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