| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10588801 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
A series of phenyl piperidine α-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13, are dual-sparing of MMP-1 and MMP-14 (MT1-MMP) and exhibit oral bioavailability in rats.
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Authors
Stephen A. Kolodziej, Susan L. Hockerman, Terri L. Boehm, Jeffery N. Carroll, Gary A. DeCrescenzo, Joseph J. McDonald, Debbie A. Mischke, Grace E. Munie, Theresa R. Fletcher, Joseph G. Rico, Nathan W. Stehle, Craig Swearingen, Daniel P. Becker,