| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10588804 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
A series of novel azobicyclo[3.3.0]octane derivatives were synthesized and evaluated as dipeptidyl peptidase 4 (DPP-4) inhibitors. The effort resulted in the discovery of inhibitor 2a, which exhibited excellent efficacies in an oral glucose tolerance test. Introduction of methyl group (2j) could prolong the inhibition of serum DPP-4 activity.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Synthesis and biological evaluation of azobicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes](/preview/png/10588804.png "First Page Preview: Synthesis and biological evaluation of azobicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes")
Authors
Tang Peng Cho, Yang Fang Long, Lin Zhi Gang, Wang Yang, Lu He Jun, Shen Guang Yuan, Fu Jian Hong, Wang Lin, Guan Dong Liang, Zhang Lei, Luo Jing Jing, Gong Ai Shen, She Gao Hong, Wang Dan, Feng Ying, Yan Pang Ke, Leng Ying, Feng Jun, Mong Xian Tai,