| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10588818 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Novel S-aryltriazole acyclonucleosides were designed as structural analogs based on the previously identified antiviral aryltriazole acyclonucleosides in our laboratories. These S-aryltriazole nucleosides were synthesized in excellent yields via SNAr-mediated S-arylation, followed by subsequent ammonolysis. X-ray structural analysis revealed special structural feature brought by the S-linkage, which may represent an unfavorable factor contributing to the lack of anti-HCV activity for this family of triazole nucleosides.
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Authors
Yang Liu, Yi Xia, Wei Li, Mei Cong, Alain Maggiani, Pieter Leyssen, Fanqi Qu, Johan Neyts, Ling Peng,