| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10588829 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Tricyclic sulfones were designed as γ-secretase inhibitors and found to have excellent potency. Extensive SAR shows that a large number of sulfonamides at position 7 of the tricycle are very well tolerated. Compounds such as 15a and 15c showed remarkable in vivo potency.
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Authors
T.K. Sasikumar, Li Qiang, Duane A. Burnett, David Cole, Ruo Xu, Hongmei Li, William J. Greenlee, John Clader, Lili Zhang, Lynn Hyde,