| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10588830 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
A series of biaryl substituted 2,5-diazabicyclo[2.2.1]heptanes were synthesized as potent and selective α7 NNR agonists. Among them, compound 18e shows a α7 binding affinity of 0.2 nM.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Syntheses and structure-activity relationship (SAR) studies of 2,5-diazabicyclo[2.2.1]heptanes as novel α7 neuronal nicotinic receptor (NNR) ligands](/preview/png/10588830.png "First Page Preview: Syntheses and structure-activity relationship (SAR) studies of 2,5-diazabicyclo[2.2.1]heptanes as novel α7 neuronal nicotinic receptor (NNR) ligands")
Authors
Tao Li, William H. Bunnelle, Keith B. Ryther, David J. Anderson, John Malysz, Rosalind Helfrich, Jens H. Grønlien, Monika Håkerud, Dan Peters, Michael R. Schrimpf, Murali Gopalakrishnan, Jianguo Ji,