| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10588834 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Complex tetracyclic sulfones were designed as γ-secretase inhibitors and a stereoselective synthesis was achieved. γ-Secretase activity was seen predominately in the (â) enantiomeric series. Compounds such as 2a and 2b showed remarkable in vitro and in vivo potency.
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Authors
T.K. Sasikumar, Duane A. Burnett, Theodros Asberom, Wen-Lian Wu, Chad Bennett, David Cole, Ruo Xu, William J. Greenlee, John Clader, Lili Zhang, Lynn Hyde,