| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10588837 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
Replacement of the core heterocycle of a defined series of chromen-4-one DNA-PK inhibitors by the isomeric chromen-2-one (coumarin) and isochromen-1-one (isocoumarin) scaffolds was investigated. Structure-activity relationships for DNA-PK inhibition were broadly consistent, albeit with a reduction of potency compared with the parent chromenone.
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Authors
Sara L. Payne, Sonsoles Rodriguez-Aristegui, Julia Bardos, Céline Cano, Bernard T. Golding, Ian R. Hardcastle, Marcus Peacock, Nahida Parveen, Roger J. Griffin,