Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10588841 | Bioorganic & Medicinal Chemistry Letters | 2010 | 6 Pages |
Abstract
A novel series of [6-chloro-2-trifluoromethyl-7-aryl-7H-imidazo[1,2-a]imidazol-3-ylmethyl]-dialkylamines was discovered as potent CRF1R antagonists. The optimization of binding affinity in the series by the parallel reaction approach is discussed herein.
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Authors
Dmitry Zuev, Vivekananda M. Vrudhula, Jodi A. Michne, Bireshwar Dasgupta, Sokhom S. Pin, Xiaohua Stella Huang, Dedong Wu, Qi Gao, Jie Zhang, Matthew T. Taber, John E. Macor, Gene M. Dubowchik,