| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10588841 | Bioorganic & Medicinal Chemistry Letters | 2010 | 6 Pages |
Abstract
A novel series of [6-chloro-2-trifluoromethyl-7-aryl-7H-imidazo[1,2-a]imidazol-3-ylmethyl]-dialkylamines was discovered as potent CRF1R antagonists. The optimization of binding affinity in the series by the parallel reaction approach is discussed herein.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Discovery of 6-chloro-2-trifluoromethyl-7-aryl-7H-imidazo[1,2-a]imidazol-3-ylmethylamines, a novel class of corticotropin-releasing factor receptor type 1 (CRF1R) antagonists](/preview/png/10588841.png "First Page Preview: Discovery of 6-chloro-2-trifluoromethyl-7-aryl-7H-imidazo[1,2-a]imidazol-3-ylmethylamines, a novel class of corticotropin-releasing factor receptor type 1 (CRF1R) antagonists")
Authors
Dmitry Zuev, Vivekananda M. Vrudhula, Jodi A. Michne, Bireshwar Dasgupta, Sokhom S. Pin, Xiaohua Stella Huang, Dedong Wu, Qi Gao, Jie Zhang, Matthew T. Taber, John E. Macor, Gene M. Dubowchik,