| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10588850 | Bioorganic & Medicinal Chemistry Letters | 2010 | 6 Pages |
Abstract
This study provides the first experimental evidence that the heterocyclic side chains present in cephalosporins not only inhibits peroxidase-catalyzed iodination reactions, but also reacts with iodine to produce stable charge-transfer complexes. The peroxidase inhibition and reactivity toward iodine must be taken into account while designing new antibiotics based on cephalosporins as these activities may adversely affect the thyroid activity.
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Authors
A. Tamilselvi, Govindasamy Mugesh,