Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10588862 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
In search for a new analgesic and anti-inflammatory agent with improved potency, we designed and synthesized a series of 3,2-(4,5-dihydro-5-(4-morphilinophenyl)-1H-pyarazol-3-yl)phenols 6(a-g) and its N-phenylpyrazol-1-carbothioamide 7(a-g) by Claisan-Schmidt condensation followed by the reaction of hydrazine hydrate. All the synthesized compounds were assayed for their in vivo analgesic and anti-inflammatory activities. All the compounds synthesized showed the potential to demonstrate analgesic and anti-inflammatory activity, of particular interest compounds 6a, 6b, 6g, 7a, 7d and 7g were found comparable to Diclofenac.
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Authors
Ratnadeep S. Joshi, Priyanka G. Mandhane, Santosh D. Diwakar, Sanjay K. Dabhade, Charansingh H. Gill,