| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10588874 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
Synthesis and structure-activity relationships of cannabinoid-1 receptor (CB1R) inverse agonists based on dihydro-pyrano[2,3-b] pyridine and tetrahydro-1,8-naphtyridine scaffolds are presented. Rat food intake and pharmacokinetic evaluation of 13g, 13i, 13k and 17a revealed these compounds to be highly efficacious orally active modulators of CB1R.
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![Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: Synthesis, SAR and biological evaluation](/preview/png/10588874.png "First Page Preview: Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: Synthesis, SAR and biological evaluation")
Authors
Christina B. Madsen-Duggan, John S. Debenham, Thomas F. Walsh, Lin Yan, Pei Huo, Junying Wang, Xinchun Tong, Julie Lao, Tung M. Fong, Jing Chen Xiao, Cathy R.-R.C. Huang, Chun-Pyn Shen, D.Sloan Stribling, Lauren P. Shearman, Alison M. Strack,