| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10588878 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
The discovery of a highly potent and selective EP4 antagonist MF-766 is discussed. This N-benzyl indole derivative exhibits good pharmacokinetic profile and unprecedented in vivo potency in the rat AIA model.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Discovery of 4-{1-[({1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl}benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain](/preview/png/10588878.png "First Page Preview: Discovery of 4-{1-[({1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl}benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain")
Authors
John Colucci, Michael Boyd, Carl Berthelette, Jean-Francois Chiasson, Zhaoyin Wang, Yves Ducharme, Rick Friesen, Mark Wrona, Jean-Francois Levesque, Danielle Denis, Marie-Claude Mathieu, Rino Stocco, Alex G. Therien, Patsy Clarke, Steve Rowland,