Neutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases: Into clinical testing with pre-adaptive pharmacophores

Article ID	Journal	Published Year	Pages	File Type
10590247	Bioorganic & Medicinal Chemistry Letters	2015	30 Pages	PDF

Keywords

PAH DMPK ARDS SIRS NCF AATD HNE AAT Acute lung injury neutrophil elastase Ali Human neutrophil elastase Induced fit Bronchiectasis Chronic obstructive pulmonary disease COPD NSCLC Acute respiratory distress syndrome Systemic inflammatory response syndrome Heterocyclic chemistry Medicinal chemistry Pulmonary arterial hypertension Biological activity Cystic fibrosis drug metabolism and pharmacokinetics Elastase inhibitors Small molecule Pulmonary hypertension non-small cell lung carcinoma Alpha-1 antitrypsin deficiency

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

Neutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases: Into clinical testing with pre-adaptive pharmacophores

Authors

Franz von Nussbaum, Volkhart M.-J. Li,