Discovery of substituted 4-aminoquinazolines as selective Toll-like receptor 4 ligands

Article ID	Journal	Published Year	Pages	File Type
10590747	Bioorganic & Medicinal Chemistry Letters	2014	8 Pages	PDF

Abstract

4-Aminoquinazolines: human TLR4 selective ligands discovered by HTS methods.

Keywords

MD-2 4-Aminoquinazolines NF-κB activation Innate immune response Toll-like receptor 4

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

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Discovery of substituted 4-aminoquinazolines as selective Toll-like receptor 4 ligands

Authors

Afshin Nour, Tomoko Hayashi, Michael Chan, Shiyin Yao, Rommel I. Tawatao, Brian Crain, Igor F. Tsigelny, Valentina L. Kouznetsova, Alast Ahmadiiveli, Karen Messer, Minya Pu, Maripat Corr, Dennis A. Carson, Howard B. Cottam,