| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10590755 | Bioorganic & Medicinal Chemistry Letters | 2014 | 5 Pages |
Abstract
A series of pyrrolo-benzo-1,4-diazine analogs have been synthesized and displayed potent Nav1.7 inhibitory activity and moderate selectivity over Nav1.5. Compound 33 displayed oral anti-nociceptive efficacy in both rat CFA pain model (100 mpk oral dosing) and SNL neuropathic pain model (EC50 75 μM).
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Shu-Wei Yang, Ginny D. Ho, Deen Tulshian, Ana Bercovici, Zheng Tan, Jennifer Hanisak, Stephanie Brumfield, Julius Matasi, Xianfeng Sun, Samuel A. Sakwa, R. Jason Herr, Xiaoping Zhou, Terry Bridal, Mark Urban, Jeffrey Vivian, Diane Rindgen, Steve Sorota,