| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10590765 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
Two new spirooxindole alkaloids spindomycins A (1) and B (2) were isolated from rhizosphere strain Streptomyces sp. xzqh-9. Their structures were elucidated by comprehensive spectroscopic analyses of NMR and MS data. The absolute configurations of 1 and 2 were determined by experimental and theoretical calculation of electronic circular dichroism (ECD). Antitumor, lactate dehydrogenase, and tyrosine kinase inhibitory activities of two compounds were evaluated, while only spindomycin B (2) exhibited weak inhibitory activity against tyrosine kinase Bcr-Abl.
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Organic Chemistry
Authors
Kai Guo, Tingting Fang, Jingyi Wang, An-an Wu, Yuezhou Wang, Jie Jiang, Xinrui Wu, Siyang Song, Wenjing Su, Qingyan Xu, Xianming Deng,