| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10590788 | Bioorganic & Medicinal Chemistry Letters | 2014 | 6 Pages |
Abstract
A novel Plumbagin-Isoniazid Analog (PLIHZ) and its β-cyclodextrin inclusion complex (PLIHZCD) is prepared, characterized and evaluated for antitubercular activity under low and high iron conditions. PLIHZCD exhibited superior activity PLIHZ and PL under 7H9 medium conditions. The standard compound INH exhibited higher MIC values under low iron conditions, whereas it's note-worthy that the new conjugate PLIHZ exhibited potent MIC value than INH under similar conditions indicating the advantage of combining plumbagin with INH to overcome INH resistance.
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Authors
Prasad Dandawate, Kiranmayi Vemuri, K. Venkateswara Swamy, Ejazuddin M. Khan, Manjula Sritharan, Subhash Padhye,