| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10590790 | Bioorganic & Medicinal Chemistry Letters | 2014 | 5 Pages |
Abstract
Synthesis and SAR investigation of 2-guanidinoquinazolines, initially identified in a high content screen for selective STAT3 pathway inhibitors, led to a more potent analog (11c) that demonstrated improved anti-proliferative activity against a panel of HNSCC cell lines.
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Authors
Matthew G. LaPorte, Dimas José da Paz Lima, Feng Zhang, Malabika Sen, Jennifer R. Grandis, Daniel Camarco, Yun Hua, Paul A. Johnston, John S. Lazo, Lynn O. Resnick, Peter Wipf, Donna M. Huryn,