| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10590801 | Bioorganic & Medicinal Chemistry Letters | 2014 | 5 Pages |
Abstract
A knowledge-based design strategy led to the discovery of several new series of potent and orally bioavailable CRTh2 antagonists where a bicyclic heteroaromatic ring serves as the central core. Structure-kinetic relationships (SKR) opened up the possibility of long receptor residence times.
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Authors
Juan Antonio Alonso, Miriam Andrés, Mónica Bravo, Maria Antonia Buil, Marta Calbet, Jordi Castro, Paul R. Eastwood, Peter Eichhorn, Cristina Esteve, Elena Gómez, Jacob González, Marta Mir, Silvia Petit, Richard S. Roberts, Bernat Vidal, Laura Vidal,