Discovery of 1-(4-(5-(5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one (AZD8835): A potent and selective inhibitor of PI3KÎ± and PI3KÎ´ for the treatment of cancers

Article ID	Journal	Published Year	Pages	File Type
10590841	Bioorganic & Medicinal Chemistry Letters	2015	12 Pages	PDF

Keywords

PIK3CA mutation PI3Kδ PI3Kα Kinase

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

Preview

Discovery of 1-(4-(5-(5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one (AZD8835): A potent and selective inhibitor of PI3KÎ± and PI3KÎ´ for the treatment of cancers

Authors

Bernard Barlaam, Sabina Cosulich, Bénédicte Delouvrié, Rebecca Ellston, Martina Fitzek, Hervé Germain, Stephen Green, Urs Hancox, Craig S. Harris, Kevin Hudson, Christine Lambert-van der Brempt, Honorine Lebraud, Françoise Magnien,