| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10590946 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
A series of pyrrolo-benzo-1,4-diazine analogs have been synthesized and displayed potent Nav1.7 inhibitory activity and moderate selectivity over Nav1.5. Compound 41 displayed anti-nociceptive efficacy in the rat CFA pain model at 100Â mpk oral dosing.
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Authors
Ginny D. Ho, Deen Tulshian, Ana Bercovici, Zheng Tan, Jennifer Hanisak, Stephanie Brumfield, Julius Matasi, Charles R. Heap, William G. Earley, Brandy Courneya, R. Jason Herr, Xiaoping Zhou, Terry Bridal, Diane Rindgen, Steve Sorota, Shu-Wei Yang,