Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10591003 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
A set of forty alkannin and shikonin oxime derivatives were firstly designed and synthesized. Their cytotoxicities against three kinds of tumor cells and a normal cell line were tested and compared with alkannin and shikonin. The cell-based investigation demonstrated that some oxime derivatives were more or comparatively effective to the lead compounds, especially their selective and excellent antitumor activities towards K562 cells with no toxicity in normal cells. We may conclude that oximate modification to the mother nucleus of alkannin and shikonin is an available approach to acquire potent antitumor agents.
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Authors
Rubing Wang, Xu Zhang, Hualong Song, Shanshan Zhou, Shaoshun Li,