| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10591018 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
We report the synthesis of 3-phenethylazetidine derivatives 2 and their biological activities against 5-HT, NE and DA transporters as well as microsomal stability, CYP inhibition, and hERG inhibition profiles. Compound 2at showed most potent triple reuptake inhibitor with good selectivity as a candidate for depression.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jun Yun, Minsoo Han, Chiman Song, Seung Hoon Cheon, Kihang Choi, Hoh-Gyu Hahn,