| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10591028 | Bioorganic & Medicinal Chemistry Letters | 2014 | 5 Pages |
Abstract
Aminochloroquinoline-kojic acid hybrids were synthesized and evaluated for β-haematin inhibition and antiplasmodial activity against drug resistant (K1) and sensitive (3D7) strains of Plasmodium falciparum. Compound 7j was the most potent compound in both strains (IC503D7 = 0.004 μM; IC50K1 = 0.03 μM) and had the best β-haematin inhibition activity (0.07 IC50/equiv vs 1.91 IC50/equiv for chloroquine). One compound 8c was found to be equipotent in both strains (IC50 = 0.04 μM).
Related Topics
Physical Sciences and Engineering
Chemistry
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Authors
Warren Andrew Andayi, Timothy J. Egan, Kelly Chibale,