Article ID Journal Published Year Pages File Type
10591037 Bioorganic & Medicinal Chemistry Letters 2014 6 Pages PDF
Abstract
A series of α-1-C-4′-arylbutyl-l-arabinoiminofuranoses 3 with functional groups attached to the phenyl ring, which are potential α-glycosidase inhibitors, was designed and synthesized by using a Negishi cross-coupling reaction as the key reaction. Arylbutyl derivatives 3a-e showed potent inhibitory activities against intestinal maltase. Among them, difluorophenylbutyl derivative 3e showed good inhibition activities against intestinal isomaltase and sucrase as compared to those of 1 and commercial drugs.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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