Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10591037 | Bioorganic & Medicinal Chemistry Letters | 2014 | 6 Pages |
Abstract
A series of α-1-C-4â²-arylbutyl-l-arabinoiminofuranoses 3 with functional groups attached to the phenyl ring, which are potential α-glycosidase inhibitors, was designed and synthesized by using a Negishi cross-coupling reaction as the key reaction. Arylbutyl derivatives 3a-e showed potent inhibitory activities against intestinal maltase. Among them, difluorophenylbutyl derivative 3e showed good inhibition activities against intestinal isomaltase and sucrase as compared to those of 1 and commercial drugs.
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Authors
Yoshihiro Natori, Toshihiro Sakuma, Yuichi Yoshimura, Kyoko Kinami, Yuki Hirokami, Kasumi Sato, Isao Adachi, Atsushi Kato, Hiroki Takahata,