Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10591060 | Bioorganic & Medicinal Chemistry Letters | 2014 | 6 Pages |
Abstract
Kynapcin-12 is a prolyl oligopeptidase (POP) inhibitor isolated from Polyozellus multiplex, and its structure was assigned as 1 having a p-hydroquinone moiety by spectroscopic analyses and chemical means. This Letter describes the total syntheses of the proposed structure 1 for kynapcin-12 and 2â²,3â²-diacetoxy-1,5â²,6â²,4â³-tetrahydroxy-p-terphenyl 2 isolated from Boletopsis grisea, revising the structure of kynapcin-12 to the latter. These syntheses involved double Suzuki-Miyaura coupling, CAN oxidation, and LTA oxidation as key steps. The inhibitory activities of synthetic compounds against POP and cancer cells were also evaluated.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Shunya Takahashi, Ayaka Yoshida, Shota Uesugi, Yayoi Hongo, Ken-ichi Kimura, Koji Matsuoka, Hiroyuki Koshino,