| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10591092 | Bioorganic & Medicinal Chemistry Letters | 2014 | 14 Pages |
Abstract
Compound 10 provides an unbound plasma concentration 16-fold in excess of the in vitro TRPA1 IC50 and demonstrates significant effect in an on-target biochemical challenge study (allyl isothiocyanate-induced flinching).
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Katrina W. Copeland, Alessandro A. Boezio, Eugene Cheung, Josie Lee, Philip Olivieri, Laurie B. Schenkel, Qian Wan, Weiya Wang, Mary C. Wells, Beth Youngblood, Narender R. Gavva, Sonya G. Lehto, Stephanie Geuns-Meyer,