| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10591113 | Bioorganic & Medicinal Chemistry Letters | 2014 | 21 Pages |
Abstract
2-Aminobenzoxazoles have been synthesized as ligands for the hepatitis C virus (HCV) internal ribosome entry site (IRES) RNA. The compounds were designed to explore the less basic benzoxazole system as a replacement for the core scaffold in previously discovered benzimidazole viral translation inhibitors. Structure-activity relationships in the target binding of substituted benzoxazole ligands were investigated.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kevin D. Rynearson, Brian Charrette, Christopher Gabriel, Jesus Moreno, Mark A. Boerneke, Sergey M. Dibrov, Thomas Hermann,