| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10591273 | Bioorganic & Medicinal Chemistry Letters | 2013 | 6 Pages |
Abstract
The synthesis, SAR, binding affinities and pharmacokinetic profiles are described for a series of cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors discovered by high throughput screening. Compounds show high levels of ex vivo target engagement in mouse plasma 20Â h post oral dose.
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Authors
John S. Debenham, Thomas H. Graham, Andreas Verras, Yong Zhang, Matthew J. Clements, Jeffrey T. Kuethe, Christina Madsen-Duggan, Wensheng Liu, Urmi R. Bhatt, Dunlu Chen, Qing Chen, Margarita Garcia-Calvo, Wayne M. Geissler, Huaibing He, Xiaohua Li,