| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10591300 | Bioorganic & Medicinal Chemistry Letters | 2013 | 6 Pages |
Abstract
Herein, we report the synthesis and structure-activity relationship studies of new analogs of boceprevir 1 and telaprevir 2. Introduction of azetidine and spiroazetidines as a P2 substituent that replaced the pyrrolidine moiety of 1 and 2 led to the discovery of a potent hepatitis C protease inhibitor 37c (EC50 = 0.8 μM).
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Lavanya Bondada, Ramu Rondla, Ugo Pradere, Peng Liu, Chengwei Li, Drew Bobeck, Tamara McBrayer, Philip Tharnish, Jerome Courcambeck, Philippe Halfon, Tony Whitaker, Franck Amblard, Steven J. Coats, Raymond F. Schinazi,