| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10591307 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
Synthesis, characterization, in vitro and in vivo biological evaluation of a heptamethine cyanine based dual-mode single-photon emission computed tomography (SPECT)/near infrared fluorescence (NIRF) imaging probe 99mTc-PC-1007 is described. 99mTc-PC-1007 exhibited preferential accumulation in human breast cancer MCF-7 cells. Cancer-specific SPECT/CT and NIRF imaging of 99mTc-PC-1007 was performed in a breast cancer xenograft model. The probe uptake ratio of tumor to control (spinal cord) was calculated to be 4.02 ± 0.56 at 6 h post injection (pi) and 8.50 ± 1.41 at 20 h pi (P < 0.0001). Pharmacokinetic parameters such as blood clearance and organ distribution were assessed.
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Authors
Yi Zhang, Li Xiao, Kosta Popovic, Xiuzhen Xie, Mahendra D. Chordia, Leland W.K. Chung, Mark B. Williams, Wei Yue, Dongfeng Pan,