Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10591319 | Bioorganic & Medicinal Chemistry Letters | 2013 | 15 Pages |
Abstract
Resveratrol (3,4â²,5 tri-hydroxystilbene), a natural plant polyphenol, has gained interest as a non-toxic agent capable of inducing tumor cell death in a variety of cancer types. However, therapeutic application of these beneficial effects remains very limited due to its short biological half-life, labile properties, rapid metabolism and elimination. Different studies were undertaken to obtain synthetic analogs of resveratrol with major bioavailability and anticancer activity. We have synthesized a series 3-chloro-azetidin-2-one derivatives, in which an azetidinone nucleus connects two aromatic rings. Aim of the present study was to investigate the effects of these new 3-chloro-azetidin-2-one resveratrol derivatives on human breast cancer cell lines proliferation. Our results indicate that some azetidin-based resveratrol derivatives may become new potent alternative tools for the treatment of human breast cancer.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Adele Chimento, Marina Sala, Isabel M. Gomez-Monterrey, Simona Musella, Alessia Bertamino, Anna Caruso, Maria Stefania Sinicropi, Rosa Sirianni, Francesco Puoci, Ortensia Ilaria Parisi, Carmela Campana, Emilia Martire, Ettore Novellino,