| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10591322 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
A scaffold hopping strategy was successfully applied in discovering 2-aminooxazole amides as potent DGAT1 inhibitors for the treatment of dyslipidemia. Further optimization in potency and PK properties resulted in a lead series with oral in vivo efficacy in a mouse postprandial triglyceridemia (PPTG) assay.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hyunjin M. Kim, Michelle D. Smith, Jae-Hun Kim, Mary Ann Caplen, Tin Yau Chan, Brian A. McKittrick, John A. Cook, Margaret van Heek, Jean Lachowicz,