| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10591343 | Bioorganic & Medicinal Chemistry Letters | 2013 | 6 Pages |
Abstract
Two galactose derivatives, a monovalent 99mTc-MAMA-MGal galactoside and a divalent 99mTc-MAMA-DGal galactoside, were synthesized and radiolabeled in high radiochemical purity (>98%). Dynamic microSPECT imaging and biodistribution study of two traces in normal and liver fibrosis mice showed that the 99mTc-MAMA-DGal revealed higher specific binding to asialoglycoprotein receptors in liver and then rapidly excreted via both hepatobiliary system and renal clearance. The results suggest that 99mTc-MAMA-DGal may be used as SPECT probes for noninvasive evaluation of asialoglycoprotein receptor-related liver dysfunction.
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Authors
Wen-Yi Chang, Hao-Wen Kao, Hsin-Ell Wang, Jenn-Tzong Chen, Wuu-Jyh Lin, Shyh-Jen Wang, Chuan-Lin Chen,