| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10591458 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
A series of zwitterionic spirocyclic compounds were synthesised. In vitro data revealed that these compounds were potent CCR1 antagonists. In particular, 2, 4, 11 and 20 inhibited CCR1 mediated chemotaxis of THP-1 cells in a functional assay.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Nafizal Hossain, Svetlana Ivanova, Ã
sa Sjöholm Timén, Jonas Bergare, Tesfaledet Mussie, Lena Bergström,