| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10591471 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
2-Arylamino-4-aryl-pyrimidines were found to be potent inhibitors of PAK1 kinase. The synthesis and SAR are described. The incorporation of a bromide at the 5-position of the pyrimidine core and in combination with a 1,2-dimethylpiperazine pendant domain yielded a lead compound with potent PAK1 inhibition and anti-proliferative activity in various colon cancer cell lines.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yong Xu, Jason M. Foulks, Adrianne Clifford, Benjamin Brenning, Shuping Lai, Bai Luo, K. Mark Parnell, Shannon Merx, Michael V. McCullar, Steven B. Kanner, Koc-Kan Ho,