Article ID Journal Published Year Pages File Type
10591477 Bioorganic & Medicinal Chemistry Letters 2013 5 Pages PDF
Abstract
In the search for a new class of histone deacetylase inhibitors, we prepared a series of simple benzofused hydroxamic acids to find an anchoring fragment of minimal molecular weight. These initial hits, all belonging to the benzothiophene class, showed very good ligand efficiencies. Following these findings, a classical fragment growing approach was performed to increase binding affinity and cytotoxicity.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
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