Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10591500 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
In this study we present the design, synthesis and biological evaluation of a small, first-generation library of small molecule aromatic amides based on the arylopeptoid skeleton. The compounds were efficiently synthesized using a highly convenient submonomer solid-phase methodology which potentially allows for access to great product diversity. The synthesized compounds were tested for their ability to activate peroxisome proliferator-activated receptors (PPARs) and they all acted as PPARγ agonists in the μM range spanning from 2.5- to 14.7-fold activation of the receptor. This is the first discovery of bioactive molecules based on the arylopeptoid architecture.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kasper Worm-Leonhard, Thomas Hjelmgaard, Rasmus K. Petersen, Karsten Kristiansen, John Nielsen,