Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10591515 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
A series of 19 new 2-{[2-(1H-imidazol-1-yl)ethyl]sulfanyl}-1H-benzimidazole derivatives was synthesized starting from the properly substituted 1,2-phenylendiamine. These compounds have hydrogen or methyl at position 1; while hydrogen, chlorine, ethoxy or methoxycarbonyl group is at position 5 and/or 6. The novel compounds were tested against protozoa Trichomonas vaginalis, Giardia intestinalis and Entamoeba histolytica. Experimental evaluations revealed strong activity for all tested compounds, having IC50 values in the nanomolar range, which were even better than metronidazole, the drug of choice for these parasites.
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Authors
Jaime Pérez-Villanueva, Alicia Hernández-Campos, Lilián Yépez-Mulia, Carlos Méndez-Cuesta, Oscar Méndez-Lucio, Francisco Hernández-Luis, Rafael Castillo,