| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10591522 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
Synthesis and antifungal activity of cyclic octapeptide derivatives of burkholdines are described. To construct cyclic octapeptides, the combination of Fmoc-SPPS and cyclization with DIC/HOBt in the solution phase was employed. Synthesized peptides were evaluated for antifungal activity with MIC values against Saccharomyces cerevisiae, Aspergillus oryzae, and Candida viswanathii. As a result, the lipid side chain and the stereochemistry of each amino acid of Bk-1097 analogues significantly affected antifungal activity.
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Authors
Hiroyuki Konno, Yusuke Otsuki, Kenta Matsuzaki, Kazuto Nosaka,