Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10591527 | Bioorganic & Medicinal Chemistry Letters | 2013 | 12 Pages |
Abstract
Novel N-alkyldeoxynojirimycins (NADNJs) based on our previous lead 3 were designed, synthesized and tested in metabolic assays and in virus cultures. NADNJs containing terminal tertiary benzamide, sulfonamide, urea, and oxazolidinone moieties were discovered to have improved metabolic stability compared to 3, while maintaining submicromolar EC50 against BVDV and Tacaribe virus; and low cytotoxicity.
Related Topics
Physical Sciences and Engineering
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Authors
Yanming Du, Hong Ye, Fang Guo, Lijuan Wang, Tina Gill, Noshena Khan, Andrea Cuconati, Ju-Tao Guo, Timothy M. Block, Jinhong Chang, Xiaodong Xu,