| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10591528 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
Two new isoflavanones (1 and 13), along with 25 known compounds (2-12, 14-27), were isolated from the EtOAc-soluble fraction of the heartwood of Dalbergia odorifera by following their potential to inhibit the LPS-induced nitric oxide production in RAW 264.7 cells. The structures of the isolated compounds were established by spectroscopic data such as 1D, 2D NMR and MS spectrometry. Among the isolated compounds, (2S)-pinocembrin (26), showed the most potent inhibitory effect with IC50 value of 18.1 μM.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chul Lee, Jin Woo Lee, Qinghao Jin, Dae Sik Jang, Sung-Joon Lee, Dongho Lee, Jin Tae Hong, Youngsoo Kim, Mi Kyeong Lee, Bang Yeon Hwang,